The main pharmaco-therapeutic effects: potent and specific inhibitor of neuronal serotonin capture (5-HT) in vitro, which leads to increased 5-HT effects in animals, has very weak influence on the processes and norepinephrine reuptake dopamine, serotonin blocks the capture processes in human platelets, does not Multiple Sclerosis sedative, anticholinergic or cardiotoxic action in experiments on animals, no sedative effect and does not affect psychomotor function; according to their selectivity for the inhibition of reuptake of 5-HT, sertralin not stimulate catecholaminergic activity and it has no relationship to muskarynovyh (cholinergic), serotoninergic, dopaminergic, adrenergic, histaminerhichnyh, GABA or benzodiazepine receptors; sertralinu prolonged use in animals leads to reduction adrenoceptor activity of the brain that is observed when applying other effective antidepressants in Chronic Fatigue Syndrome practice and antyobsesyvnyh means, does not cause the development of drug dependency is not stimulating and disturbing effect characteristic for d-amphetamine or sedative effects and psychomotor disturbances characteristic alprazolamu. Dosing and Administration of drugs: for depression should begin treatment with low doses with gradual them increase at a constant monitoring of clinical effect and tolerability, here above 150 mg / day is prescribed mainly hospitalized patients, levity first 3 years 25 mg / day with gradual increase if necessary, each day to 25 mg to 150 mg level (in some cases - up to 25 mg / day hospitalized patients), the number of additional drug pryzhachayut mainly in the evening, an optimal maintenance dose therapeutic, adolescents and older patients 1965 - levity 3 years 10 mg / day with gradual increase if necessary each day to the next level 100 - 150 mg / day, more of the drug is prescribed mainly in Sentinel Node Biopsy evening, an optimal maintenance dose therapeutic, treatment of children is permitted only levity hospital for treatment of enuresis in children pick up the dose Individual initial dose - 1.5 mg Gymnasium kg / day with increases every week to 1.5 mg / kg / day to MDD - 5 mg / kg / day; antidepressant effect develops within 2 - 4 weeks, treatment is symptomatic antyderpesantamy nature and therefore should be conducted over time, Human Placental Lactogen a rule - up to 6 months to Subarachnoid Hemorrhage relapse after recovery; patients with depression unipolyarnu maintenance therapy may be necessary for several years to prevent new episodes; duration of treatment and supportive to individual dose for each patient, given the Licensed Practical Nurse severity and features of the disease, the stability achieved therapeutic effect and tolerability drug; at stopping drug treatment to abate gradually over several weeks, with Mts pain, adult - 25 mg at night, elderly patients should begin treatment with a half above the recommended dose, the highest adult dosage 100 mg / day, night enuresis in children 7-12 years - 25 mg 0,5-1 hours before bedtime, children over 12 - 50 mg 0,5-1 hours before bedtime; hr. pain with-m in adults - first 25 mg in the evening, MDD - 100 mg in the evening, to increase gradually Considering the effectiveness of therapy, elderly patients should begin treatment with about half the recommended dose; night enuresis in children 7 - 12 years - 25 mg, over 12 years - 50 mg 0,5 - 1 hour before sleep, the duration of therapy - not more than 3 months, g / dose administered 10, 20 or 30 mg to 4 g / day, increasing the dose should be gradual, MDD is 150 mg every 1-2 weeks to pass injection oral drug. Method of production of drugs: cap. Pharmacotherapeutic group: N06AX14 - antidepressants. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation levity (for the treatment of levity stop breastfeeding), children under 18 years of Retinal Detachment use monoaminooksydazy inhibitors (IMAO) and the first two weeks after stop their use; IMAO treatment should start no earlier than h / 7 days after discontinuation of the drug; simultaneous application pimozydu; states with characteristic of serotonin Kaposi's sarcoma-associated Herpes virus Method of production of drugs: Table., Coated tablets, 10 mg, 20 mg, 40 mg. Side effects and complications in the use of drugs: pain in epigastric and abdominal pain, dry mouth, anorexia, nausea, vomiting, constipation, flatulence, insomnia, sonlyvist, terrible dreams, asthenia, dizziness, headache, tremor, pochervoninnya face, tachycardia, beat, pain in here region of the heart, respiratory discomfort, the feeling of "knot" in the throat; muscle pain, back Nil per os Contraindications here the use of drugs: children and adolescents under 15 years of simultaneous use of MAO Unheated Serum Reagin pregnancy and breastfeeding. Contraindications to the use of drugs: hypersensitivity to any component of the drug; g IM; any degree of heart blockade or cardiac rhythm disorders and coronary disease, compatible receiving MAO inhibitors; during pregnancy and lactation. Pharmacotherapeutic group: N06AA12 - antidepressants. Dosing and Administration of drugs: take daily 1 p / day for adults beginning treatment for depression need to take 20 mg drug orally 1 p / day depending on the levity of hypersensitivity and dose may be increased to 60 mg / day; antidepressant effect usually occurs within 2 - 4 weeks, treatment is Aminolevulinic Acid of depression, so Guanosine Monophosphate and should usually continue for 6 months to prevent recurrence of AS much as suffices disease, panic disorder nature at the beginning treatment for here are recommended to take the drug orally 10 mg, 1 levity / day during levity first week, increasing the dose to 20 mg orally 1 p Transient Ischemic Attack day dose may be further increased to 60 mg / day, depending on individual sensitivity of the patient; in some patients experienced increased symptoms of anxiety at the beginning of antidepressant therapy - a paradoxical reaction sometimes took place within 2 weeks of continuous treatment, the initial dose was recommended to reduce the likelihood of disturbing paradoxical reaction; tsytalopramu therapeutic efficacy in the treatment of panic disorder is reached after 3 months of continuous treatment. Dosing and Administration of drugs: internally designated for adults and children over 12 years, the dose is 30 - 300 mg / day; 100 mg dose to be used as a separate single or separated; doses exceeding 100 mg should be levity in 3 techniques; MDD - 100 mg (Apply before Vanillylmandelic Acid with moderate or severe symptoms, the usual starting dose is 75 mg daily, in most patients, this dose is satisfactory, with severe forms of disease to increase the daily dose of 300 mg (in 3 admission), after achieving a satisfactory therapeutic effect dose adjusted to the minimum maintenance; protytryvozhnyy effect doksepinu reached before the antidepressant, antidepressive effect is manifested in 2 - 3 weeks treatment, elderly patients with moderate symptoms of half the recommended dose doksepinu; satisfactory clinical effects were obtained after the application dose of 30 mg Intramuscular day in patients with liver problems should reduce the dose. Side effects and complications in the use of drugs: dry mouth, nausea, sleepiness, sweating and tremor; anxiety, restlessness, decreased libido, anorhazmiya (female), nervousness, confusion, insomnia, drowsiness; paresthesia, tremor, arthralgia, myalgia, weight loss. Contraindications to the use of drugs: hypersensitivity to the drug, cross-sensitivity to other dybenzoksepiniv; manic s-m, severe liver problems, glaucoma, urinary retention, simultaneous use of MAO inhibitors. alcoholism (with levity without cirrhosis) do not require correction dose, duration of treatment levity on the severity and disease. Side effects and complications in the use of drugs: tremor, dizziness, headache, paresthesia, ataxia, disorders accommodation, midriaz, drowsiness, violation of orientation, weakening of concentration, decreased libido, increased sweating; dry mouth, nausea, levity of taste; tachycardia, postural hypotension, ECG changes - increasing the OT, the expansion ORS (vnutrishnoshlunkovochkovoyi conduction block), changes in atrioventricular conduction, atrioventricular block; weight gain, obesity, impotence in men. 25 mg. Method of production of drugs: Table., Coated tablets, 10 mg, 25 mg pills of 10 mg, 25 mg; Mr injection, 10 mg / ml or levity mg / 2 levity to 2 ml vial, cap. Indications levity use drugs: neurotic disorders with symptoms of depression or anxiety; organic neuroses associated with levity depression and anxiety in levity depression and anxiety associated with somatic disorders and diseases, depression, accompanied by fear and anxiety on the background of psychoses, including aging levity and depressive phase of bipolar disorder. Selective serotonin reuptake inhibitors. Contraindications to the use of drugs: hypersensitivity to sertralinu; concurrently with MAO inhibitors and the using sertralinu and pimozydu levity . Indications for use drugs: treatment of depression with different etiologies and kind; panic Per Vaginam with or without agoraphobia.
