50 mg. Indications for use drugs: rheumatoid joint inflammation with severe course. per day (morning and evening), then switching to a tab. per day (morning and evening), then switching to a tab. Method of production of drugs: cap. per plebes minimum course duration 6 weeks maximum clinical actions observed after the drug for 2-3 months, the clinical effect occurs slowly and can persist long after discontinuation, is recommended to start treatment with 2 tab. 2 g / day during the main meal for a long time (at least 6 months) considering that the drug can speed up the passage of intestinal contents during the first two weeks, we recommend starting treatment with 1 kaps. Side effects and complications in the use of drugs: moderate signs of AR (skin rash, itching, hives, etc.), disruption of gastrointestinal tract (nausea, abdominal pain, flatulence). Contraindications to the use of drugs: hypersensitivity to the drug, renal insufficiency in the stage of decompensation. Side effects and complications in the use of drugs: fever, joint pain, erythema, urticaria and / or itching, swelling of lymph nodes, inflammation of the mucous membrane of the mouth; agranulocytosis: farynhodyniya and fever with or without fever, ulcers, traumatic wounds or white spots on the red border of lips or mouth, aplastic anemia, hemolytic anemia; hlomerulopatiya, urinary tract infection, nephrotic c-m leukopenia, thrombocytopenia, obliterative bronchioles, exfoliative dermatitis c-m Goodpasture, cholestatic jaundice; myastenia gravis; c- m lyell, optic nerve neuritis, pancreatitis, ulcer recurrence. The main pharmaco-therapeutic effects: chondroprotective, improving microcirculation. Pharmacotherapeutic group: M01CB01 - specific antirheumatic drugs. Indications for use drugs: degenerative-dystrophic diseases of the spine and peripheral joints (osteoarthritis, osteochondrosis, spondylarthritis, etc.) Osteopathic and hondropatiyi, chondromalacia, parodontopatiyi, prevention and treatment of without pain damage due to physical overload (including sports injuries); period recovered after bone fractures (for faster callus formation), injuries, operations musculoskeletal, etc. Side effects and complications in the use of drugs: moderate signs of AR (skin rash, itching, hives, etc.), disruption of gastrointestinal tract (nausea, abdominal pain, flatulence). Pharmacotherapeutic group: M01AX25 - nonsteroidal anti-inflammatory and antirheumatic drugs. The main pharmaco-therapeutic effects: protyurolitychna, dezintoksykatsiy in respect to heavy metals has a high complexing activity of copper ions, mercury, lead, iron and calcium, the ability of the drug to form chelate compounds of copper makes it the tool of choice for treatment hepatolentykulyarnoyi degeneration (Wilson disease); penitsylamin reduces resorption of copper from food and promotes the removal of body tissues, the drug is effective in severe form of lead poisoning, poisoning with other heavy metals - iron, mercury, penitsylaminu mechanism of action in rheumatoid inflammation of the joints is not understood, but probably the drug increases the activity of lymphocytes reduces the concentration of rheumatoid factor (IgM) and IgG complexes in serum and joint fluid with a slight decrease in the total concentration of IgG in serum, inhibits the activity of T lymphocytes without affecting B-lymphocytes, in patients tsystynuriyu penitsylamin forms complexes with cystine. Dosing plebes Administration of drugs: Adults internally Table 1-2. Method of production of drugs: Table., Coated tablets, 250 mg. per day, duration of individual courses and tune in to the doctor determines, depending on the stage of disease, pain with th and clinical response, plebes the form of Mr injection, 0.1 g / ml injected g / 1 ml a day, in Hematemesis and Melena of good tolerance dose increased to 2 ml from chervertoyi injection; treatment -25-35 injection, repeated courses - 6 months; clinical data on drug use in'yektsiynoh form missing children.
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